Clinical evaluation of an allergen Challenge TheatreTM
نویسندگان
چکیده
Methods A preliminary evaluation of the capabilities of the newly constructed Red Maple Trials Allergen Challenge Theatre was performed. Health Canada and a provincial Ethics Board approved the study. After signing informed consent, patients with a history of grass allergy, not on allergy medications and with a positive skin prick test to grass antigen (≥ 3 mm) were exposed for 3 hours to timothy grass pollen (Phleum pratense) in the allergen challenge theatre. Total nasal (TNSS) and rhinoconjunctivitis symptom scores (TRSS) were recorded at baseline and every 30 minutes during the challenge.
منابع مشابه
Technical evaluation of an allergen Challenge TheatreTM
Methods A technical evaluation of the capabilities of the Red Maple Trials Allergen Challenge Theatre was performed. The theatre is a 4-zone facility holding up to 99 seats in a series of elevated rows. Grass (Phleum pratense) and ragweed (Ambrosia artemisiifolia) pollens were injected into the air supply and blown into the facility through ducts located across the top of the front wall. Grass ...
متن کاملApplicability and reproducibility of biomarkers for the evaluation of anti-inflammatory therapy in allergic rhinitis.
BACKGROUND We aimed to study the reproducibility of several biomarkers of allergic rhinitis to investigate their potential as outcome measures in clinical intervention trials. Furthermore, we investigated the kinetics of the biomarkers studied in nasal lavage and brush material following a placebo-controlled nasal allergen challenge. METHODS We performed a skin prick test and measured serum s...
متن کامل5-BDBD ameliorates an OVA-induced allergic asthma by the reduction of Th2 cytokines production
Objective(s): P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Materials and Methods: Ovalbumin was used to sensitize and challenge for a mouse model. Intranasal application of 5-BDBD, P2X4R antag...
متن کاملMolecular Cloning, Characterization, and Expression of Cuc m 2, a Major Allergen in Cucumis melo
Background: Several studies reported the clinical features of IgE-mediated hypersensitivity after ingestion of melon. Melon allergy is a common IgE-mediated fruit allergy in Iran. This prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the IgE-binding capacity of the natural protein with the recombinant allergen, and to determine ...
متن کاملEarly onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber.
BACKGROUND The efficacy and safety of a 5-grass-pollen sublingual immunotherapy (SLIT) tablet (Stallergènes SA, Antony, France) have been evaluated in clinical studies during the pollen season. The allergen challenge chamber (ACC) has been developed as a pharmacodynamic assessment tool to control the environmental allergens and to avoid all problems associated with unpredictable pollen seasons....
متن کامل